Living with interstitial cystitis can be challenging, but there is hope. We're about to embark on a journey through the world of supplements – those little powerhouses that can make a difference in alleviating your IC/BPS symptoms. If you're seeking relief from your symptoms or want to begin addressing your root causes, we explore the best supplements to help you do that and regain control of your well-being.
Before initiating any new supplement regimen, it's essential to prioritize your health and safety. Always consult your healthcare provider as the first step; they can offer personalized guidance tailored to your needs and medical history. Additionally, they can ensure that the supplements you're considering are safe to take and do not interact negatively with any medications you may currently be using.
Start slow
Starting slowly and gradually introducing supplements into your routine is wise. Begin with one supplement at a time, and consider cutting the initial dose into halves or even fourths. This cautious approach allows your body the necessary time to adapt and minimizes the risk of any adverse reactions. Experiencing a flare from a supplement doesn't necessarily mean you should dismiss it altogether. Instead, consider adjusting your approach by reducing the dosage and gradually increasing it over time. It's not uncommon for symptoms to temporarily worsen before improvement occurs. The key objective is to provide your body with the essential nutrients it needs to function optimally and restore your health. Finding the right balance is the ultimate goal in the journey toward well-being, and this may involve patience and experimentation to determine the best approach for your individual needs. Finally, introducing too many new substances to your body at once can be overwhelming. Starting with one supplement at a time helps your body focus on processing and adjusting to that specific supplement rather than dealing with multiple changes simultaneously.
Recognize fear
Acknowledge and recognize your fear, as fear and anxiety can activate physical responses in the body, potentially leading to interstitial cystitis/ bladder pain syndrome (IC/BPS) flares. When the brain processes fear, it can set off a chain reaction of physiological changes, including the increased production of stress hormones and heightened sensitivity to potential triggers. In IC/BPS, this fear-induced stress response can contribute to symptom flares, even when there is no actual physical threat or danger. It's essential to understand that fear itself can exacerbate symptoms, emphasizing the significant role of the mind-body connection in managing health. Reassuring your body that you are safe and employing relaxation techniques like deep breathing can help you effectively manage these fear-induced flares. By calming the nervous system, you can potentially mitigate the impact of anxiety and fear on your health. Maintaining a positive and confident mindset and a sense of safety can contribute to more positive experience when trying new supplements or making dietary changes.
Seeking professional help from a trained therapist is an excellent step if you find fear or anxiety affecting your well-being. Therapists can provide valuable tools and techniques to help calm the nervous system and manage stress effectively. It's worth noting that nervous system dysregulation is a common factor in many individuals with interstitial cystitis/bladder pain syndrome, and addressing these emotional aspects can be a crucial part of a comprehensive treatment plan. A therapist can work with you to develop coping strategies, reduce stress, and improve overall emotional and mental health, contributing to a better quality of life.
Supplements for Balancing Whole Body Health
NAC
Glutathione, often called the "Master Antioxidant," is a peptide composed of three essential amino acids. Its primary role lies in combating oxidative stress and neutralizing harmful free radicals. N-acetylcysteine (NAC), a precursor to glutathione, plays a pivotal role in this process. It's a powerful antioxidant that can help prevent cellular-level free radical damage, bolster the body's defense against infections, and support the liver in efficiently detoxifying harmful substances. You can boost glutathione with other antioxidants, such as selenium, NAC, and alpha-lipoic acid, further enhancing its effectiveness.
Sulfora-Clear
Designed to give your body a specific amount of glucoraphanin and active myrosinase enzyme. These substances work together to create sulforaphane, a powerful compound that activates your body's own antioxidant and detoxification systems. Sulforaphane is linked to various health benefits often seen in broccoli and similar vegetables, such as improved detoxification and better protection against harmful substances, promoting overall well-being. My preferred brand of choice is Metagenics.
Probiotic
Probiotics support individuals with gut dysbiosis, immune system problems, and conditions like Interstitial Cystitis (IC). These beneficial bacteria can help restore a balanced gut microbiome, which is essential for optimal digestion and absorption of nutrients. They may alleviate symptoms like diarrhea, constipation, and bloating associated with gut issues. Probiotics also play a role in enhancing the immune response by modulating inflammation and supporting immune system regulation. In the context of interstitial cystitis, they can indirectly influence bladder health by reducing inflammation throughout the body and balancing the gut microbiome. I prefer probiotics from reputable brands that are either spore-based or have a high CFU count of 100 billion and feature at least ten different strains to ensure comprehensive support for gut health.
Fish oil
Fish oil, rich in omega-3 fatty acids like EPA and DHA, offers dual benefits when taken systemically. Firstly, it's renowned for its potent anti-inflammatory properties, which can help reduce chronic inflammation, mitigating the risk of various inflammatory conditions. Secondly, fish oil is a powerful ally for brain health. The omega-3s in fish oil are essential for brain function, promoting cognitive health, memory, and mood stability. Regular supplementation can enhance overall well-being by combating systemic inflammation and nurturing brain health. My preferred brand of choice is Arazo Nutrition.
Milk Thistle
A natural herb known for its liver-supporting properties, is vital in detoxification. Its active compound, silymarin, acts as a powerful antioxidant and helps protect liver cells from damage caused by toxins and free radicals. Moreover, milk thistle aids in promoting the regeneration of healthy liver tissue. Enhancing liver function supports the body's ability to filter and remove harmful substances, making it an invaluable ally in detoxification.
Quercetin with Nettles
Quercetin with nettles is a dietary supplement combining flavonoid quercetin with stinging nettle extract. Quercetin is known for its antioxidant properties and potential anti-inflammatory effects while stinging nettle is valued for its ability to alleviate allergy symptoms and support overall health. Together, they may offer a synergistic approach to promoting well-being. Quercetin is also recognized for its antihistamine properties, as it can help block the release of histamine, a chemical involved in allergic reactions. When combined with nettles, which also has antihistamine properties, this supplement can be particularly effective in managing allergies, histamine intolerance, and related symptoms.
Bromelain
Bromelain is an enzyme extracted from pineapples, and when taken in conjunction with quercetin, it can enhance the effectiveness of quercetin. Quercetin is a flavonoid known for its antioxidant and anti-inflammatory properties, including its role as a natural antihistamine.
When combined with bromelain, quercetin's absorption and bioavailability are improved. Bromelain assists in breaking down quercetin, which can be challenging for the body to absorb independently. This synergy allows for more efficient absorption of quercetin into the bloodstream, potentially enhancing its therapeutic effects. As a result, the combination of quercetin and bromelain is often used as a natural remedy for various health concerns, including allergy relief, anti-inflammatory support, and immune system modulation.
Mega IgG2000
IgG antibodies can attach themselves to harmful substances like bacteria, viruses, fungi, and the toxins they produce. This attachment neutralizes these toxins, making it safe for the immune system to eliminate them from the body. MegaIgG2000™️ is designed to promote a healthy mucosal immune system by reducing unnecessary immune responses and fortifying the protective barrier in the gut. I like to take it at night before bed. My brand of choice is MegaIgG2000™️from Microbiome Labs.
Vitamin A
Vitamin A is a key player in supporting immune health. It contributes to a robust defense system by promoting the production and function of white blood cells, which are essential for combating infections. Additionally, it helps maintain the integrity of mucous membranes that act as barriers to pathogens in the respiratory, digestive, and urinary tracts. Vitamin A's immune-boosting properties extend to its role in regulating the immune response, ensuring it is both effective against invaders and appropriately controlled to prevent excessive inflammation. Adequate vitamin A intake is crucial for a well-balanced immune system, making it vital to overall health and resilience against illnesses. My brand of choice is Pure Encapsulations.
CoQ10
Coenzyme Q10 (CoQ10) is a natural compound found in the body that plays a crucial role in cellular energy production. Some studies have indicated that CoQ10 may have antioxidant and anti-inflammatory properties, which could be relevant in addressing IC symptoms that involve inflammation and oxidative stress in the bladder lining.
Detox
Many individuals turn to a detox or cleanse program to kickstart healthier habits and address symptoms of toxicity or sluggishness. Detox Ultra Clear Renew is a preferred detox supplement for many individuals including myself, due to its gentle nature and the ability to maintain regular meals. This metabolic detox supplement supports the body's natural detox processes by providing a comprehensive blend of nutrients, including vitamins, minerals, antioxidants, amino acids, and phytonutrients. A metabolic detox focuses on promoting healthy cellular function and metabolic processes, helping the body eliminate toxins and waste products more efficiently. However, a key piece of advice for anyone considering this supplement is to start slowly and give your body the time it needs to adapt. Remember, detoxification is a gradual process, and patience is crucial for achieving the best results.
Magnesium
Magnesium Glycinate: This form of magnesium is known for its high bioavailability and gentle, calming effect. It's often recommended for promoting relaxation, reducing stress, and improving sleep quality. Magnesium glycinate may be a good choice if you're looking to address mood and sleep concerns.
Magnesium Citrate: Magnesium citrate is another well-absorbed form of magnesium. It may help with muscle relaxation and stress reduction. Some individuals find it effective for improving sleep quality as well. *Avoid if you struggle with histamine intolerance.
Magnesium Taurate: Magnesium taurate combines magnesium with the amino acid taurine, which has potential mood-stabilizing effects. This form may benefit those seeking to support mood and overall relaxation.
Magnesium L-threonate: Primarily acknowledged for its cognitive advantages, Magnesium L-threonate's unique capability to penetrate the blood-brain barrier can also have indirect benefits for mood and stress management. This extraordinary property improves magnesium delivery to brain cells, making it a valuable asset for memory, cognitive function, and overall brain health.
Digestive Enzymes
Digestive enzymes can be a valuable support for individuals with leaky gut syndrome, a condition characterized by increased intestinal permeability. A leaky gut can lead to various health issues due to the passage of undigested particles into the bloodstream. Digestive enzymes help by enhancing nutrient absorption, reducing digestive stress, promoting thorough protein digestion, and supporting individuals with underlying digestive disorders often associated with leaky gut. Additionally, they may contribute to reducing inflammation in the gut, a primary concern in leaky gut syndrome. My brand of choice is Dr. Amy Myers, MD Complete Enzymes (chewable).
DAO Enzyme
DAO, which stands for Diamine Oxidase, is a specialized digestive enzyme that plays a crucial role in managing histamine levels in the body. When histamine intolerance is a concern, DAO supplements can be fast-acting allies in maintaining comfort and gastrointestinal relief. To make the most of their benefits, take one capsule approximately 15 minutes before indulging in histamine-rich foods or beverages, or as advised by your healthcare provider. This proactive approach helps minimize the risk of histamine intolerance, which can manifest with various symptoms, affecting the digestive system, skin, respiratory tract, and more. Common signs include abdominal discomfort, bloating, itching, hives, nasal congestion, headaches, fatigue, and mood changes. My brand of choice is SeekingHealth (Histamine Digest).
HCL
HCL, which stands for Hydrochloric Acid, is a digestive enzyme naturally produced by the stomach to aid in the digestion of food. It plays a crucial role in breaking down proteins and activating other digestive enzymes. HCL supplements are sometimes used to support digestion in individuals with low stomach acid production, a condition known as hypochlorhydria. These supplements typically contain synthetic HCL along with other digestive enzymes like pepsin. They are usually taken with meals to enhance the digestion of proteins and other nutrients. Signs that you have low stomach acid may include bloating, belching, indigestion, and difficulty digesting certain foods. Nutritional deficiencies, recurring infections, and specific diagnostic tests can also provide clues.
Elderberry
Elderberry is a well-regarded natural remedy known for its potential role in supporting and bolstering the immune system. Rich in antioxidants, particularly flavonoids like quercetin and anthocyanins, elderberry possesses anti-inflammatory and antiviral properties that can help the body defend against infections. It is often used to alleviate symptoms of the common cold and flu and may reduce the duration and severity of these illnesses when taken promptly at the onset of symptoms. Elderberry's immune-boosting benefits make it a valuable building block for maintaining robust immune function. My brand of choice is Gaia.
Liposomal Vitamin C
Liposomal vitamin C is a unique and advanced form of vitamin C supplementation. Unlike traditional vitamin C supplements, liposomal vitamin C is encapsulated within tiny lipid (fat) particles. This encapsulation enhances the absorption and bioavailability of vitamin C in the body, allowing for more efficient delivery of this essential nutrient to cells and tissues. As a potent antioxidant, vitamin C plays a crucial role in supporting the immune system, promoting collagen production for healthy skin, and combating oxidative stress. Liposomal vitamin C has gained popularity as it can provide these benefits with a reduced risk of gastrointestinal discomfort that some individuals may experience with other forms of vitamin C. It offers a convenient and effective way to incorporate this vital nutrient into your daily health regimen, supporting overall well-being. Buffered vitamin C is a variation of liposomal vitamin C and includes alkaline compounds like calcium or magnesium ascorbate. These compounds help neutralize the acidity of vitamin C, making it gentler on the stomach and bladder while retaining the enhanced absorption benefits of liposomal delivery. This combination offers a well-tolerated and effective way to harness the immune-boosting and antioxidant properties of vitamin C. My preferred brand of choice is Quicksilver Scientific Liposomal Vitamin C, which is a liquid form of buffered Vitamin C containing 1000mg.
Vitamin B
Vitamin B is a group of essential water-soluble vitamins that play vital roles in maintaining overall health and well-being. This group includes eight distinct B vitamins, each with its specific functions and benefits. B vitamins are renowned for their role in energy metabolism, helping convert the food we eat into energy that fuels our bodies. Additionally, they support the nervous system, contribute to the production of essential neurotransmitters like serotonin and dopamine, and play crucial roles in cell function. Folate, a member of the B vitamin family, is particularly vital for its role in supporting healthy development and functioning of the nervous and immune systems. Given their diverse functions, B vitamins are essential for maintaining energy, cognitive function, and overall health, making them a crucial part of a well-rounded nutritional regimen. My preferred brand of choice is Integrative Therapeutics Active B-Complex.
Vitamin D3/K2
Vitamin D3 is a cornerstone of immune health, playing a multifaceted role in bolstering our body's defense mechanisms. It acts as a regulator, fine-tuning our immune response to pathogens ensuring it strikes the right balance between defense and inflammation. With inherent antimicrobial properties, vitamin D3 directly targets and neutralizes specific invaders. Moreover, it empowers key immune cells, like T-cells and macrophages, enabling them to identify and combat threats effectively. Beyond these functions, it aids in inflammation control, a critical aspect of immune health. Ensuring the integrity of our physical barriers, such as the skin and mucous membranes, is yet another dimension of its immune support. Vitamin D3 is an indispensable ally for maintaining a robust immune system. Still, its supplementation should be undertaken judiciously and under the guidance of a healthcare provider to address individual health needs and concerns. The combination of vitamin D3 and vitamin K2 further enhances immune health by supporting the immune response and promoting overall well-being through optimal calcium utilization and bone health. My brand of Choice is Metagenics D3/K2 5,000 IU.
Zinc
Zinc, an essential mineral, contributes to overall gastrointestinal well-being in several ways. While it's not typically considered a primary nutrient for gut health, it plays crucial roles in supporting digestive function and maintaining the integrity of the gastrointestinal system:
Zinc is vital for a robust immune system, which is closely linked to gut health, helping to protect against infections and promoting a balanced gut microbiome.
It acts as a cofactor for digestive enzymes, facilitating the breakdown of carbohydrates, fats, and proteins.
Zinc plays a role in preserving the integrity of the intestinal barrier, preventing increased permeability of the intestinal lining often associated with "leaky gut" syndrome.
SAM-e
Or S-Adenosyl Methionine, is a dietary supplement known for its diverse potential health benefits. It is often used to support mood and emotional well-being by promoting the production of neurotransmitters like serotonin and dopamine. This makes it a popular choice for those seeking natural approaches to managing depression and mood disorders. Thanks to its anti-inflammatory properties, SAM-e also holds promise in promoting joint health and reducing joint pain associated with conditions like osteoarthritis. Additionally, it plays a role in liver function, making it beneficial for liver-related conditions, and has been explored for its potential cognitive benefits and applications in managing fibromyalgia.
Adrenal Support
Adrenal support supplements are valuable allies for individuals grappling with stress and fatigue. By incorporating adaptogenic herbs, vitamins, and minerals, these supplements work to restore balance in adrenal gland function. They help regulate stress hormone levels, promoting resilience against stressors and diminishing feelings of anxiety and fatigue. Additionally, the inclusion of energy-boosting nutrients sustains vitality and combats weariness. Improved sleep quality is often a beneficial side effect, thanks to relaxation-promoting ingredients, and mood stabilization components may help manage stress-related mood swings. Ultimately, adrenal support supplements contribute to a holistic approach to stress management and enhanced well-being. My brand of choice is Cortisol Manager by Integrative Therapeutics or Adrenal Px Balance by Restorative Formulations.
Supplements for a Happy Bladder
Aloe Vera
It is known for its potential benefits in supporting bladder health, particularly for individuals dealing with conditions like Interstitial Cystitis (IC) or chronic bladder irritation. Aloe vera's soothing and anti-inflammatory properties can help alleviate symptoms associated with these conditions, such as pain, urgency, and frequent urination. It may have a calming effect on the bladder lining, reducing irritation and discomfort. My brand of choice is Dessert Harvest, Aloe Vera.
Marshmallow root
Marshmallow root can support bladder health through its soothing and anti-inflammatory properties. It contains mucilage, a gel-like substance that can coat and protect the bladder lining, helping to alleviate irritation and inflammation. This may reduce common bladder-related symptoms such as pain, urgency, and frequent urination. Marshmallow root is known for its mucilage content, a gel-like substance that can coat and soothe the digestive tract. It may help alleviate symptoms of heartburn, indigestion, and gastrointestinal irritation.
D'Mannose
D-mannose is a natural sugar found in various fruits, including cranberries and corn, and is often used as a dietary supplement for its potential health benefits, primarily related to urinary health. It is known for its ability to help prevent and manage urinary tract infections (UTIs). D-mannose works by adhering to bacteria in the urinary tract, particularly E. coli, which is a common cause of UTIs. By binding to these bacteria, D-mannose can help flush them out of the body, reducing the risk of infection and alleviating UTI symptoms. My brand of Choice is West Coast Mint.
Slippery Elm
Slippery elm, an herbal remedy, has been utilized to support bladder health, especially in cases of urinary tract discomfort or irritation. This herb contains mucilage, which forms a soothing gel-like substance when mixed with water. This mucilage can coat and calm irritated tissues, including the urinary tract lining, potentially alleviating discomfort associated with conditions like interstitial cystitis. Furthermore, slippery elm boasts mild anti-inflammatory properties that may help reduce inflammation in the bladder and urinary tract, providing relief from associated symptoms. Its traditional use also suggests a positive impact on the health of mucous membranes in the urinary tract, contributing to overall bladder well-being.
Kava
kava may promote GABA activity, helping stabilize mast cells and potentially reducing histamine release, which plays a role in inflammation and allergies. Moreover, kavalactones in kava can bind to cannabinoid receptors in the bladder, potentially alleviating urinary pain, reducing nerve impulses to urinary muscles, and relaxing the bladder. Overall, kava's multifaceted effects make it a potentially valuable option for individuals with IC, particularly those with pelvic floor hypertonicity.
Uva Ursi
Also known as bearberry, is an herbal remedy often used to support urinary and bladder health. The leaves of the Uva ursi plant contain compounds like arbutin, which have antimicrobial properties and can help inhibit the growth of bacteria in the urinary tract. This makes uva ursi a popular choice for addressing urinary tract infections (UTIs) and other urinary discomfort. Its diuretic properties may also help flush out the urinary system. However, it's important to use uva ursi under the guidance of a healthcare provider, as prolonged or excessive use can lead to side effects. Additionally, uva ursi should not replace professional medical treatment for UTIs or other urinary conditions, but it can be a complementary approach when used responsibly.
CystoProtek
CystoProtec is a dietary supplement formulated to support bladder health and provide relief from symptoms associated with various bladder conditions. It typically contains a combination of natural ingredients, such as chondroitin sulfate, glucosamine sulfate, quercetin, and other botanical extracts. These components are believed to work together to help maintain the health and integrity of the bladder lining, reduce inflammation, and alleviate discomfort commonly experienced by individuals with conditions like interstitial cystitis (IC) or other bladder-related issues.
L-arginine
L-arginine is an amino acid that plays various roles in the body, including its involvement in the production of nitric oxide, a molecule that helps relax blood vessels. Some people have used L-arginine as a potential dietary supplement for interstitial cystitis (IC) due to its role in improving blood flow and potentially reducing inflammation.
Chinese Herbs
Herbal tea and pills have been used to treat IC patients for years as a treatment alternative. One pilot study utilized the herbs Cornus, gardenia, curculigo, rhubarb, Psoralea, and Rehmannia in a tea twice a day for 6 days a week for 3 months, then once a day. Of 25 patients, 61% had a significant decrease in pain at 4 weeks, and an additional 22% had a significant response at 3 months. These promising results suggest that herbal therapy, utilizing the combination of these specific herbs, may offer a valuable and natural approach to managing interstitial cystitis, providing hope for improved quality of life for those who seek alternative treatments.
Wrapping it up
Opting for individual vitamins and supplements instead of a multivitamin offers a personalized approach to nutrition and health management. This method allows for precise targeting of specific nutrient needs or health goals, enabling the customization of dosages to meet individual requirements without excess or waste. Additionally, it facilitates the identification of any sensitivities or adverse reactions to particular nutrients, aiding in the avoidance of problematic ingredients. This tailored approach also helps manage potential nutrient interactions and ensures cost-effectiveness by investing in supplements that directly align with one's health priorities, ultimately fostering a more effective and efficient path to well-being and a happy bladder.
In conclusion, supplements offer many options to support your health and well-being. However, it's important to remember that each person's needs are unique, and what works wonders for one individual may yield different results for another. The ultimate aim is to bring the body into a state of balance that allows it to heal and function optimally. Addressing any nutrient deficiencies is a key part of achieving this equilibrium. As you embark on your supplement journey, make sure to consult with a healthcare provider who can offer personalized guidance based on your specific health goals and requirements. Additionally, it's not advisable to take all these supplements simultaneously; rather, as your body heals and rebalances, you may find that your needs change, and you require fewer supplements. You will also find that you are able to tolerate certain supplements that you couldn't before. By approaching supplements with care and attention, you can work toward achieving the best possible state of health and well-being for yourself.
Sources
Katske F, Shoskes DA, Sender M, Poliakin R, Gagliano K, Rajfer J. Treatment of interstitial cystitis with a quercetin supplement. Tech Urol. 2001 Mar;7(1):44-6. PMID: 11272677.
Theoharides TC, Sant GR. A pilot open label study of Cystoprotek in interstitial cystitis. Int J Immunopathol Pharmacol. 2005 Jan-Mar;18(1):183-8. doi: 10.1177/039463200501800119. PMID: 15698523.
Korting GE, Smith SD, Wheeler MA, Weiss RM, Foster HE Jr. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol. 1999 Feb;161(2):558-65. PMID: 9915448.
Whitmore KE. Complementary and alternative therapies as treatment approaches for interstitial cystitis. Rev Urol. 2002;4 Suppl 1(Suppl 1):S28-35. PMID: 16986031; PMCID: PMC1476005.